Kaya, H. et al. FASCIATA genes for chromatin assembly factor-1 in Arabidopsis maintain the cellular organization of apical meristems.Developing red blood cells in your bone marrow do have nuclei, but the nuclei disintigrate when they are fully developed: this is because the nuclei are not needed any more.Using the Arabidopsis thaliana root meristem as a model system, her laboratory aims to shed light on the molecular mechanisms that are involved in balancing cell division with cell differentiation necessary to support continuous plant organ growth.Regulation of CLV3 expression by two homeobox genes in Arabidopsis.Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output.Intercellular movement of the putative transcription factor SHR in root patterning.
Animal Stem Cell Research - KOMU.comThe organizing centre (OC) signals to maintain the overlying stem cells, which generate transit-amplifying cells that will eventually differentiate and give rise to entire organs, for example a leaf.
This strategy may offer a way to reprogram available cells into other cell types that have been lost or damaged due to disease.We have seen above that there are intriguing similarities in the way stem cells function in both plants and animals to sustain growth and replace tissues.Wildwater, M. et al. The RETINOBLASTOMA-RELATED gene regulates stem cell maintenance in Arabidopsis roots.
Rubin, a neurobiologist leading the drug screening at the Harvard Stem Cell Institute.In addition to reprogramming cells to become a specific cell type, it is now possible to reprogram adult somatic cells to become like embryonic stem cells ( induced pluripotent stem cells, iPSCs ) through the introduction of embryonic genes.Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers.Renze Heidstra Renze Heidstra is an assistant professor in plant developmental biology at Wageningen University and Research centre, The Netherlands.As they do in humans, adult stem cells reside in animals bone marrow, where they are released whenever there is a problem somewhere in the body.
Stem Cell of America - Breakthrough Stem Cell TreatmentsInduction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Galweiler, L. et al. Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue.
Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: absorptive cells, goblet cells, Paneth cells, and enteroendocrine cells.
Reducing Animal Testing Using Stem Cells | January 15Industry aims to capitalize on the promise of these potent cells.FEWER CAGES Using embryonic stem cells as in vitro models of disease and in drug toxicological testing may reduce the number of rats used in research.
Ten Problems with Embryonic Stem Cell Research | TheThe energy produced by mitochondria is released into the cell in the form of ATP (Adenosine Tri-Phosphate).The Case for Adult Stem Cell Research. by. It has become clear from transplantation experiments with animals, that stem cells of a particular tissue can develop.Identifies the PLT genes as key effectors for the establishment of the root stem cell niche during embryonic pattern formation.RPK2 is an essential receptor-like kinase that transmits the CLV3 signal in Arabidopsis.
Stem cells may provide a complementary alternative to animals as in vitro models of disease and for toxicological testing.Alternative splicing as a regulator of development and tissue identity.The history of research on adult stem cells began more than 60 years ago.Researchers are defining the chemical preferences of stem cells and figuring out what keeps them eternal and what destines them to a differentiated fate.Currently, the most successful development of stem cells as in vitro models for toxicology testing is in human cardiac tissue.
In all cases, stem cells (purple) are maintained by short-range signals that arise from specialized organizing cells (pink) that act cell non-autonomously.Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis.They can grow and differentiate in a petri dish into the variety of cells that build a human organ.Stem cells, however, may turn out to be a promising alternative to animal testing.A tissue contains many cells all of the same kind and all doing the same jobs.
The nuclei of the secretory cells in your salivary gland contain the information about how to make these two proteins in their DNA.Could stem cell research end animal experimentation some day.
Gifford, Casey, A. et al. Transcriptional and epigenetic dynamics during specification of human embryonic stem cells.Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling.Bayer, M. et al. Paternal control of embryonic patterning in Arabidopsis thaliana.